About Me

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I was 53 in June. I feel like I'm 30. I live in Cold Cold Wisconsin. But, I love it here.. I found fabric and quilting about 8 years ago.. I fell in love with it.. I also enjoy paper art.. I'm not sure how I kept my sanity before I started doing art. I found rubber stamps about 10 years ago and have gone on to anything and everything.. I have been blessed with creative talents and love to express myself in art. I have 2 children .. one girl who is 15 and a boy who is 17. My husband and I love to hunt,canoe and just enjoy the outdoors together.. We all love the outdoors and go up to northern Wisconsin as often as possible. I'm a 14 year breast cancer survivor.. you can view more of my art at http://laurakrasinskiquilts.blogspot.com www.picturetrail.com/barngirl or my teaching, lecture and vending schedule here http://laurakrasinskisartontherun.blogspot.com

Monday, December 13, 2010

More On Alzheimers Art Quilt Initiative.. Awesome News..

I copied and am pasting this from AAQI Blog...

FOR IMMEDIATE RELEASE:

(Burton, MI)-- December 14, 2010 -- A $30,000 research grant awarded by the Alzheimer's Art Quilt Initiative (AAQI) to the University of Michigan has yielded positive results! The award helped finance research led by U-M Life Sciences Institute assistant professor Mi Hee Lim which was published online in the December 3rd edition of the Proceedings of the National Academy of Science.

Dr Lim and her team created new molecular tools that show promise for cleansing the brain of amyloid plaques. These plaques, a hallmark of Alzheimer's disease, are clumps of misfolded proteins thought to cause cell death leading to devastating memory loss and cognitive decline.

The mechanisms responsible for the formation of these misfolded proteins, and their associations with Alzheimer's disease, are not entirely understood. It is thought that copper and zinc ions are somehow involved. Funding of Dr. Lim's study which explored the roles of metal ions in Alzheimer's disease was the third grant made by the Alzheimer's Art Quilt Initiative since it became a nonprofit three years ago.

In earlier work, Lim and her team developed dual-purpose molecular tools that both grab metal ions and interact with amyloid-beta. The researchers went on to show that in solutions with or without living cells, the molecules were able to regulate copper-induced amyloid-beta aggregation, not only disrupting the formation of clumps, but also breaking up clumps that already had formed.

Building upon that first generation of compounds, Lim and lab members Jung-Suk Choi (postdoctoral scholar) and Joseph Braymer (graduate student) now report a second generation of compounds that are more stable in biological environments. The researchers tested one of those compounds, described in the PNAS paper, in homogenized brain tissue samples from Alzheimer's disease patients.

"We found that our compound is capable of disassembling the misfolded amyloid clumps to form smaller amyloid pieces, which might be 'cleansed' from the brain more easily, demonstrating a therapeutic application of our compound," said Lim, who has joint appointments in the Life Sciences Institute and the Department of Chemistry. In addition, preliminary tests show that the bi-functional small molecules have a strong potential to cross the blood-brain barrier, the barricade of cells that separates brain tissue from circulating blood, protecting the brain from harmful substances in the bloodstream."

"Crossing this barrier is essential for any treatment like this to be successful," Lim said.

Next steps include more intensive testing of the new compounds for diagnostic and therapeutic properties.

The Alzheimer's Art Quilt Initiative (www.AlzQuilts.org) is a national, grassroots organization whose mission is to raise awareness and fund research. It auctions and sells donated quilts through the Priority: Alzheimer's Quilt project and sponsors a nationally touring exhibition of quilts about Alzheimer's called “Alzheimer’s Illustrated: From Heartbreak to Hope.” The AAQI has raised almost $500,000 since January 2006. Ami Simms of Flint, Michigan is the founder and executive director of the AAQI, a 501(c)(3) nonprofit corporation operated entirely by volunteers. She is a quilter. Her mother had Alzheimer's.

For more information on the AAQI or to make a donation, contact Ami Simms at 810-637-5586 (9 a.m – 3 p.m. Eastern), ami@alzquilt.org or www.alzquilts.org.



Read more: http://www.alzquilts.org/limgrant.html#ixzz182SOw4lo

2 comments:

Ami said...

Laura, thanks so much for spreading the word! We are so thrilled. We now have proof that the work we do with a needle and thread can truly make a difference!

Ami Simms
Founder & Executive Director
AAQI
www.AlzQuilts.org

Brighton said...

Hi Laura -

Thank you for your support. Have you made a Priority Quilt yet? If so, which one. If not please do as I am sure it will sell right away and raise big dollars.

Niki Gottesman
Board Member
AAQI
www.AlzQuilts.org